A copper-catalysed ring-opening trifluoromethylation reaction of cyclopropanols has been developed. Various β-trifluoromethyl ketones are obtained in good to excellent yields under mild reaction conditions. The present method also exhibits good functional-group compatibility. The mechanism of this new ring-opening trifluoromethylation reaction was investigated by radical trapping reactions.
X. He, Y. Shu, J. Dai, W. Zhang, Y. Feng and H. Xu, Org. Biomol. Chem., 2015, 13, 7159 DOI: 10.1039/C5OB00808E
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