An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes

Abstract

An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes was developed. The transformation employs only AgSCF₃ and KI in situ generated active nucleophilic trifluoromethylthio species and cleanly occurs in up to quantitative yield at room temperature, thereby providing an unprecedentedly easy entry to various α-SCF₃-substituted ketones/arylmethanes.