Issue 30, 2015
From the journal:

Organic & Biomolecular Chemistry

Lysosome targeting fluorescence probe for imaging intracellular thiols†

Dnyaneshwar Kand,‡a   Tanmoy Saha,‡a   Mayurika Lahirib  and  Pinaki Talukdar*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411008, India
E-mail: ptalukdar@iiserpune.ac.in

b Department of Biology, Indian Institute of Science Education and Research Pune, Pune 411008, India

Abstract

A BODIPY-based fluorescence turn-on probe, exhibiting high selectivity and sensitivity towards intracellular thiols with excellent lysosomal localization is reported. The probe displayed fast response towards biothiols in aqueous solution. Localization of the probe in lysosome was demonstrated by intracellular colocalization studies with the aid of LysoSensor Green.

Graphical abstract: Lysosome targeting fluorescence probe for imaging intracellular thiols

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Article information

DOI
https://doi.org/10.1039/C5OB00889A
Article type
Communication
Submitted
02 May 2015
Accepted
25 Jun 2015
First published
25 Jun 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 8163-8168

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Lysosome targeting fluorescence probe for imaging intracellular thiols

D. Kand, T. Saha, M. Lahiri and P. Talukdar, Org. Biomol. Chem., 2015, 13, 8163 DOI: 10.1039/C5OB00889A

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