A simple and efficient synthetic route to substituted N-sulfinyl and N-sulfonyl azetidines is described involving imino-aldol reaction of ester enolates with racemic and non-racemic aldimines for obtaining β-amino esters as a key step. These β-amino esters on subsequent reduction followed by TsCl/KOH mediated cyclization produced the corresponding racemic and non-racemic azetidines with high yield and stereoselectivity.
M. K. Ghorai, S. Das, K. Das and A. Kumar, Org. Biomol. Chem., 2015, 13, 9042 DOI: 10.1039/C5OB01140J
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