Issue 31, 2015
From the journal:

Organic & Biomolecular Chemistry

A facile approach to β-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid†

Jie Dai,a   Wenlong Ren,a   Haining Wanga  and  Yian Shi*abc  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

b Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

c Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
E-mail: Yian.Shi@colostate.edu

Abstract

An effective Pd(0)-catalyzed hydrocarboxylation of enimides with formic acid in the presence of a catalytic amount of HCOOPh is described. A variety of β-amino acid derivatives are obtained in good yields with high regioselectivities without using external toxic CO gas.

Graphical abstract: A facile approach to β-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid

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Article information

DOI
https://doi.org/10.1039/C5OB01304F
Article type
Communication
Submitted
26 Jun 2015
Accepted
09 Jul 2015
First published
09 Jul 2015

Org. Biomol. Chem., 2015,13, 8429-8432

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A facile approach to β-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid

J. Dai, W. Ren, H. Wang and Y. Shi, Org. Biomol. Chem., 2015, 13, 8429 DOI: 10.1039/C5OB01304F

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