Issue 34, 2015
From the journal:

Organic & Biomolecular Chemistry

Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization†

Jiaqi Wang,‡a   Shaoru Wang,‡a   Cheng Zhong,‡a   Tian Tian*a  and  Xiang Zhou*a  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn, ttian@whu.edu.cn
Fax: (+)86-27-68756663
Tel: (+)86-27-68756663

Abstract

Here, we have provided novel insights into the effects of 8-oxodG substitutions on B–Z transitions of CpG dinucleotide DNAs. A combination of different techniques including a CD study, a PAGE analysis, DFT calculations and molecular modeling has been collectively used.

Graphical abstract: Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization

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Article information

DOI
https://doi.org/10.1039/C5OB01340B
Article type
Communication
Submitted
02 Jul 2015
Accepted
27 Jul 2015
First published
28 Jul 2015

Org. Biomol. Chem., 2015,13, 8996-8999

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Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization

J. Wang, S. Wang, C. Zhong, T. Tian and X. Zhou, Org. Biomol. Chem., 2015, 13, 8996 DOI: 10.1039/C5OB01340B

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