Copper-catalyzed C(sp3)–H functionalization of ketones with vinyl azides: synthesis of substituted-1H-pyrroles

Abstract

Copper-catalyzed C(sp³)–H functionalization of ketones with vinyl azides for the synthesis of substituted pyrroles has been developed. The method is a straightforward and efficient way to access a series of 2,3,5-trisubstituted-1H-pyrroles in modest to excellent yields with broad functional group tolerance under mild conditions.