Issue 44, 2015
From the journal:

Organic & Biomolecular Chemistry

Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones†

Masaaki Yohdaa  and  Yasunori Yamamoto*b  

* Corresponding authors

a Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-8628, Japan

b Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
E-mail: yasuyama@eng.hokudai.ac.jp
Fax: +81-11-706-8117

Abstract

Ruthenium/Me-BIPAM-catalyzed asymmetric addition of arylboronic acids to methyl 2-formylbenzoates afforded chiral 3-aryl-isobenzofuranones. [RuCl2(p-cymene)]2/Me-BIPAM and RuCl2(PPh3)3/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities.

Graphical abstract: Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones

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Article information

DOI
https://doi.org/10.1039/C5OB01661D
Article type
Paper
Submitted
07 Aug 2015
Accepted
07 Sep 2015
First published
07 Sep 2015

Org. Biomol. Chem., 2015,13, 10874-10880

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Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones

M. Yohda and Y. Yamamoto, Org. Biomol. Chem., 2015, 13, 10874 DOI: 10.1039/C5OB01661D

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