Issue 1, 2015

Gold-catalyzed highly efficient benzylation of alcohols with N-Cbz-N-benzyl-propargylamine

Abstract

N-Cbz-N-benzyl-propargylamine is easily synthesized and described as a benzylating reagent. The treatment of the novel reagent with various alcohols in the presence of the IPrAuNTf2 catalyst affords benzyl ethers in high yields. The protocol derives practical benefits from the mild conditions and the high functional group tolerance, and also eliminates the need for excess base additives or moisture-sensitive promoters.

Graphical abstract: Gold-catalyzed highly efficient benzylation of alcohols with N-Cbz-N-benzyl-propargylamine

Supplementary files

Article information

Article type
Research Article
Submitted
26 Sep 2014
Accepted
11 Nov 2014
First published
12 Nov 2014

Org. Chem. Front., 2015,2, 34-37

Gold-catalyzed highly efficient benzylation of alcohols with N-Cbz-N-benzyl-propargylamine

J. Zhao, X. Yuan, Z. Wang, S. Chen, Z. Zhang and W. Xue, Org. Chem. Front., 2015, 2, 34 DOI: 10.1039/C4QO00255E

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