Issue 1, 2015
From the journal:

Organic Chemistry Frontiers

Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation†

Mingyu Yang,a   Xingyu Jianga  and  Zhang-Jie Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing, China
E-mail: zshi@pku.edu.cn
Web: http://www.shigroup.cn/
Fax: (+86)-10-6276-0890

b State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, China

Abstract

Selective modifications of life's basic components, such as polypeptides, are of great importance in both chemistry and biology. Herein, we have developed an unprecedented intramolecular amidation of the phenylalanine moiety in dipeptides via Pd-catalyzed sp2 C–H activation and C–N formation.

Graphical abstract: Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation

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Article information

DOI
https://doi.org/10.1039/C4QO00282B
Article type
Research Article
Submitted
30 Oct 2014
Accepted
27 Nov 2014
First published
28 Nov 2014

Org. Chem. Front., 2015,2, 51-54

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Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation

M. Yang, X. Jiang and Z. Shi, Org. Chem. Front., 2015, 2, 51 DOI: 10.1039/C4QO00282B

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