A NIS/CHP-mediated [4 + 1]-cycloaddition of isocyanides with 1,2-diaza-1,3-dienes generated in situ from hydrazones under metal-free conditions has been developed. This protocol provides a new, atom efficient and step efficient way to construct aminopyrazoles in good to excellent yields via formation of new C–C/C–N bonds, utilizing a catalytic amount of NIS in the presence of CHP.
T. Zhu, T. Wei, S. Wang and S. Ji, Org. Chem. Front., 2015, 2, 259 DOI: 10.1039/C4QO00289J
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