Issue 3, 2015

Oxidative C(sp3)–H functionalization of acetonitrile and alkanes with allylic alcohols under metal-free conditions

Abstract

An efficient method for the construction of ketonitriles and α-aryl ketones by tert-butyl peroxybenzoate (TBPB) mediated direct alkylation of acetonitrile and alkanes with α,α-diaryl allylic alcohols has been developed. The reactions involve C(sp3)–H functionalization and radical addition/1,2-aryl migration processes under metal-free conditions.

Graphical abstract: Oxidative C(sp3)–H functionalization of acetonitrile and alkanes with allylic alcohols under metal-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
29 Nov 2014
Accepted
05 Jan 2015
First published
06 Jan 2015

Org. Chem. Front., 2015,2, 216-220

Oxidative C(sp3)–H functionalization of acetonitrile and alkanes with allylic alcohols under metal-free conditions

X. Chu, H. Meng, Y. Zi, X. Xu and S. Ji, Org. Chem. Front., 2015, 2, 216 DOI: 10.1039/C4QO00314D

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