Oxidative cross S–H/S–H coupling: selective synthesis of unsymmetrical aryl tert-alkyl disulfanes

Abstract

Selective oxidative coupling between aryl and tert-alkyl mercaptans was achieved using tert-butyl hydroperoxide (TBHP) as the oxidant and N-iodosuccinimide (NIS) as a catalyst. This protocol may provide an efficient process to synthesize unsymmetrical aryl tert-alkyl disulfanes.