Kinetic resolution of racemic 5-alkylcyclohexenones via Pd(ii)-catalyzed 1,4-additions of arylboronic acids – access to trans 3-alkyl-5-arylcyclohexanones†
Abstract
The kinetic resolution of racemic 5-substituted alkylcyclohexenones via 1, 4-conjugate addition with a variety of arylboronic acids was achieved by utilizing a ferrocenyl phosphapalladacycle catalyst. The addition reaction proceeded smoothly to afford trans-3-alkyl-5-arylcyclohexanones in good yields and selectivities.