Issue 12, 2015

Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2

Abstract

A general and efficient method for the synthesis of quinazolinones via acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes in water has been accomplished. In the presence of [Cp*Ir(H2O)3][OTf]2, a variety of desirable products were obtained in high yields with high atom economy under environmentally benign conditions. Notably, this research will facilitate the progress of acceptorless dehydrogenative reactions in water catalyzed by water-soluble organometallic complexes.

Graphical abstract: Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2

Supplementary files

Article information

Article type
Research Article
Submitted
13 Aug 2015
Accepted
06 Oct 2015
First published
06 Oct 2015

Org. Chem. Front., 2015,2, 1589-1597

Author version available

Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2

F. Li, L. Lu and J. Ma, Org. Chem. Front., 2015, 2, 1589 DOI: 10.1039/C5QO00255A

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