CuSO4-H-phosphonate catalyzed highly stereo- and regioselective dimerization of terminal alkynes

Abstract

The readily available CuSO₄-H-phosphonate catalytic system can catalyze the head-to-head dimerization of terminal alkynes to give the corresponding (E) conjugated enynes selectively in high yield. The present protocol provides an efficient and practical approach to various conjugated enynes with the advantages of cheap catalysts, operational simplicity and high stereo-and regioselectivity.