Issue 6, 2015
From the journal:

RSC Advances

A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change†

Qi-Hua You,ab   Yee Man Lee,c   Wing Hong Chan,*ab   Nai Ki Mak,*c   Albert W. M. Lee,a   Sam C. K. Hauad  and  Thomas C. W. Makd  

* Corresponding authors

a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

b Partner State Key Laboratory of Environmental and Bioanalysis, Kowloon Tong, Hong Kong, China

c Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

d Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China

Abstract

A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.

Graphical abstract: A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

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Article information

DOI
https://doi.org/10.1039/C4RA13445A
Article type
Communication
Submitted
30 Oct 2014
Accepted
08 Dec 2014
First published
08 Dec 2014

RSC Adv., 2015,5, 4099-4102

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A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change

Q. You, Y. M. Lee, W. H. Chan, N. K. Mak, A. W. M. Lee, S. C. K. Hau and T. C. W. Mak, RSC Adv., 2015, 5, 4099 DOI: 10.1039/C4RA13445A

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