Issue 26, 2015
From the journal:

RSC Advances

Co-delivery of drug nanoparticles and siRNA mediated by a modified cell penetrating peptide for inhibiting cancer cell proliferation†

Dafeng Chu,a   Wen Xu,a   Ran Pana  and  P. Chen*a  

* Corresponding authors

a Department of Chemical Engineering and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
E-mail: p4chen@uwaterloo.ca

Abstract

Co-delivery of anti-cancer agent Ellipticine (EPT) and Bcl-2 siRNA was mediated by a modified cell penetrating peptide, stearylated H16R8 (STR-H16R8). The stability and efficacy of the EPT nanoparticles was improved significantly by the amphiphilic peptide. Efficacy of STR-H16R8 stabilized EPT nanoparticles was further enhanced with Bcl-2 siRNA.

Graphical abstract: Co-delivery of drug nanoparticles and siRNA mediated by a modified cell penetrating peptide for inhibiting cancer cell proliferation

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Article information

DOI
https://doi.org/10.1039/C4RA14827D
Article type
Communication
Submitted
18 Nov 2014
Accepted
16 Feb 2015
First published
16 Feb 2015

RSC Adv., 2015,5, 20554-20556

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Co-delivery of drug nanoparticles and siRNA mediated by a modified cell penetrating peptide for inhibiting cancer cell proliferation

D. Chu, W. Xu, R. Pan and P. Chen, RSC Adv., 2015, 5, 20554 DOI: 10.1039/C4RA14827D

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