Issue 13, 2015
From the journal:

RSC Advances

Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide†

Yuma Tachikawa,a   Yoshitomo Nagasawa,a   Sohei Furuhashi,a   Lei Cui,a   Eiji Yamaguchi,a   Norihiro Tada,a   Tsuyoshi Miurab  and  Akichika Itoh*a  

* Corresponding authors

a Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan
E-mail: itoha@gifu-pu.ac.jp
Fax: +81-058-230-8108
Tel: +81-058-230-8108

b Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
E-mail: tmiura@toyaku.ac.jp
Fax: +81-042-676-4479
Tel: +81-042-676-4479

Abstract

We have developed a metal-free synthetic method for 3-nitroimidazo[1,2-a]pyridines from nitroalkenes and 2-aminopyridines using catalytic amounts of iodine and aqueous hydrogen peroxide as a terminal oxidant.

Graphical abstract: Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide

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Article information

DOI
https://doi.org/10.1039/C4RA14970J
Article type
Communication
Submitted
21 Nov 2014
Accepted
23 Dec 2014
First published
05 Jan 2015

RSC Adv., 2015,5, 9591-9593

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Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide

Y. Tachikawa, Y. Nagasawa, S. Furuhashi, L. Cui, E. Yamaguchi, N. Tada, T. Miura and A. Itoh, RSC Adv., 2015, 5, 9591 DOI: 10.1039/C4RA14970J

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