Synthesis, characterization, and application of Fe3O4-SA-PPCA as a novel nanomagnetic reusable catalyst for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines

Abstract

Piperidine-4-carboxylic acid (PPCA) functionalized Fe₃O₄ nanoparticles (Fe₃O₄-PPCA) were prepared by the one pot co-precipitation of iron oxide in the presence of PPCA. Grafting of chlorosulfonic acid on the synthesized Fe₃O₄-PPCA nanoparticles afforded sulfamic acid-functionalized magnetic nanoparticles (Fe₃O₄-SA-PPCA). The catalytic activity of Fe₃O₄-SA-PPCA as a novel catalyst was probed through one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines derivatives. The heterogeneous catalyst could be recovered easily and reused many times without significant loss of its catalytic activity.