Targeted dextran-b-poly(ε-caprolactone) micelles for cancer treatments

Abstract

In this study, targeted drug deliveries with excellent biocompatibility have been investigated to improve the efficacy and reduce the systemic toxicity of drugs. First, amphiphilic dextran-b-poly(ε-caprolactone) (Dex-PCL) copolymers were synthesized by a “click” reaction between α-alkyne terminated dextran and azido-terminated poly(ε-caprolactone). Then, the targeted molecules, such as folic acid and galactose, were conjugated to Dex-PCL. To verify their feasibility as drug delivery vehicles, DOX was loaded into Dex-PCL micelles with or without a targeted molecule. The in vitro release of DOX from DOX-loaded micelles demonstrated that there was a continuous release after burst release in the first 6 h. The cell viability assay of DOX-loaded micelles conjugated with targeting molecules against HeLa and HepG2 cells was investigated. Targeted DOX-loaded micelles showed significant bindings with tumor cells and efficient inhibition to corresponding targeted cells. Therefore, targeted DOX-loaded micelles provided an efficient drug delivery platform for the inhibition of cancer cells.