Issue 20, 2015
From the journal:

RSC Advances

Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans†

Xiantao Lei,ab   Chun-Huan Jiang,a   Xiaoan Wen,a   Qing-Long Xu*a  and  Hongbin Sun*a  

* Corresponding authors

a Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, State Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China
E-mail: qlxu@cpu.edu.cn, hbsun2000@yahoo.com

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, 555 Zuchongzhi Road, Shanghai 201203, China

Abstract

An efficient and straightforward method for the rapid synthesis of 2-substituted dihydrobenzofurans has been developed via reaction of sulfur ylides with o-quinone methides (o-QMs), which were generated under mild conditions. The products could be obtained in excellent yields with various kinds of sulfur ylides.

Graphical abstract: Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans

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Article information

DOI
https://doi.org/10.1039/C4RA17003B
Article type
Paper
Submitted
24 Dec 2014
Accepted
22 Jan 2015
First published
22 Jan 2015

RSC Adv., 2015,5, 14953-14957

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Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans

X. Lei, C. Jiang, X. Wen, Q. Xu and H. Sun, RSC Adv., 2015, 5, 14953 DOI: 10.1039/C4RA17003B

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