Issue 37, 2015
From the journal:

RSC Advances

Trifluoromethyl syn- or anti-γ-amino alcohols by one-pot solvent-free Mannich-type reactions under temperature control†

Stefania Fioravanti,*a   Luca Parise,a   Alessia Pelagalli,a   Lucio Pellacania  and  Laura Trullia  

* Corresponding authors

a Dipartimento di Chimica, Università degli Studi di Roma “La Sapienza”, P.le Aldo Moro 5, I-00185 Roma, Italy
E-mail: stefania.fioravanti@uniroma1.it
Fax: +39 06490631
Tel: +39 0649913098

Abstract

Starting from trifluoroacetaldehyde ethyl hemiacetal, chiral amines and suitable aldehydes, diastereomerically pure fluorinated syn- or anti-γ-amino alcohols can be obtained by a friendly one-pot solvent-free L-proline catalysed Mannich-type reaction only by changing the temperature.

Graphical abstract: Trifluoromethyl syn- or anti-γ-amino alcohols by one-pot solvent-free Mannich-type reactions under temperature control

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Article information

DOI
https://doi.org/10.1039/C5RA01791B
Article type
Communication
Submitted
29 Jan 2015
Accepted
17 Mar 2015
First published
17 Mar 2015

RSC Adv., 2015,5, 29312-29318

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Trifluoromethyl syn- or anti-γ-amino alcohols by one-pot solvent-free Mannich-type reactions under temperature control

S. Fioravanti, L. Parise, A. Pelagalli, L. Pellacani and L. Trulli, RSC Adv., 2015, 5, 29312 DOI: 10.1039/C5RA01791B

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