Issue 35, 2015
From the journal:

RSC Advances

Regioselective three-component reactions of enaminones, 2-aminopyridines and enals for the synthesis of 1,2-dihydropyridines†

Shuo Cao,a   Luoting Xin,a   Yunyun Liu,a   Jie-Ping Wan*a  and  Chengping Wen*b  

* Corresponding authors

a Key Laboratory of Functional Small Organic Molecules, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P R China
E-mail: wanjieping@gmail.com, wanjieping@jxnu.edu.cn

b College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, P R China
E-mail: cpwen.zcmu@yahoo.com

Abstract

A three-component synthetic method involving the assembly of enals, N,N-disubstituted enaminones and 2-aminopyridines has been designed, which leads to the facile and regioselective synthesis of 1,2-dihydropyridines (1,2-DHPs) with broad scope and generally good yields in the presence of simple acid catalysts.

Graphical abstract: Regioselective three-component reactions of enaminones, 2-aminopyridines and enals for the synthesis of 1,2-dihydropyridines

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Article information

DOI
https://doi.org/10.1039/C5RA01901J
Article type
Communication
Submitted
30 Jan 2015
Accepted
10 Mar 2015
First published
10 Mar 2015

RSC Adv., 2015,5, 27372-27374

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Regioselective three-component reactions of enaminones, 2-aminopyridines and enals for the synthesis of 1,2-dihydropyridines

S. Cao, L. Xin, Y. Liu, J. Wan and C. Wen, RSC Adv., 2015, 5, 27372 DOI: 10.1039/C5RA01901J

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