Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones†
Abstract
A new Ni-catalyzed asymmetric decarboxylative Mannich reaction between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoro-acetaldimine and β-keto-acids was developed, which was carried out at room temperature affording β-trifluoromethyl-β-amino ketones with excellent yields and diastereoselectivities.