Issue 46, 2015
From the journal:

RSC Advances

Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant†

Junliang Lv,a   Ying Liang,*a   Peiling He,a   Zhihao Cai,a   Jianwen Liua  and  Fengxi Huanga  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. of China
E-mail: liangyinggdpu@126.com

Abstract

A direct C-3 alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones through palladium-catalyzed C–H activation using oxygen as the terminal oxidant has been developed. This method provides an easy access to functionalized new 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one derivatives.

Graphical abstract: Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant

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Article information

DOI
https://doi.org/10.1039/C5RA02932E
Article type
Communication
Submitted
15 Feb 2015
Accepted
14 Apr 2015
First published
14 Apr 2015

RSC Adv., 2015,5, 36171-36174

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Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant

J. Lv, Y. Liang, P. He, Z. Cai, J. Liu and F. Huang, RSC Adv., 2015, 5, 36171 DOI: 10.1039/C5RA02932E

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