Issue 46, 2015
From the journal:

RSC Advances

Nitroaldol (Henry) reaction of 2-oxoaldehydes with nitroalkanes as a strategic step for a useful, one-pot synthesis of 1,2-diketones†

Alessandro Palmieri,*a   Serena Gabrielli,a   Susanna Sampaolesia  and  Roberto Ballini*a  

* Corresponding authors

a “Green Chemistry Group”, School of Science and Technology, Chemistry Division, University of Camerino, via S. Agostino 1, 62032 Camerino, MC, Italy
E-mail: alessandro.palmieri@unicam.it, roberto.ballini@unicam.it
Fax: +39 0737 402297

Abstract

The nitroaldol (Henry) reaction of 2-oxoaldehydes with a variety of nitroalkanes, under basic heterogeneous conditions and microwave irradiation, affords 1,2-diketones in a one-pot way. The key step of the process involves the nitrous acid elimination from the nitroalkanol intermediates instead of the standard water elimination.

Graphical abstract: Nitroaldol (Henry) reaction of 2-oxoaldehydes with nitroalkanes as a strategic step for a useful, one-pot synthesis of 1,2-diketones

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Article information

DOI
https://doi.org/10.1039/C5RA03772G
Article type
Communication
Submitted
03 Mar 2015
Accepted
14 Apr 2015
First published
15 Apr 2015
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2015,5, 36652-36655

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Nitroaldol (Henry) reaction of 2-oxoaldehydes with nitroalkanes as a strategic step for a useful, one-pot synthesis of 1,2-diketones

A. Palmieri, S. Gabrielli, S. Sampaolesi and R. Ballini, RSC Adv., 2015, 5, 36652 DOI: 10.1039/C5RA03772G

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