Issue 40, 2015

DDQ-mediated synthesis of functionalized unsymmetrical disulfanes

Abstract

We developed a simple and efficient method for the synthesis of functionalized unsymmetrical disulfanes under mild conditions in good yields. The designed method is based on the reaction of bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)disulfane with thiols in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ). The developed method allows the preparation of unsymmetrical disulfanes bearing additional hydroxy, carboxy, or amino functionalities.

Graphical abstract: DDQ-mediated synthesis of functionalized unsymmetrical disulfanes

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2015
Accepted
25 Mar 2015
First published
25 Mar 2015

RSC Adv., 2015,5, 31347-31351

Author version available

DDQ-mediated synthesis of functionalized unsymmetrical disulfanes

M. Musiejuk, T. Klucznik, J. Rachon and D. Witt, RSC Adv., 2015, 5, 31347 DOI: 10.1039/C5RA04173B

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