Facile “on water” domino reactions for the expedient synthesis of 2H-thiopyrano[2,3-b]quinolines

Abstract

A facile synthesis of novel 3-nitro-2-aryl-2H-thiopyrano[2,3-b]quinolines from the domino reactions of 2-mercaptoquinoline-3-carbaldehyde and substituted β-nitrostyrenes in the presence of triethylamine (TEA) in water is described. This “on water” protocol proceeds with high atom economy through the creation of one C–S and one C–C bond presumably via a Michael addition-intramolecular aldol-dehydration domino sequence.