A highly selective CHEF-type chemosensor for monitoring Zn2+ in aqueous solution and living cells

Jae Jun Lee; Seul Ah Lee; Hyun Kim; LeTuyen Nguyen; Insup Noh; Cheal Kim

doi:10.1039/C5RA05080D

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A highly selective CHEF-type chemosensor for monitoring Zn²⁺ in aqueous solution and living cells†

Jae Jun Lee,^a Seul Ah Lee,^a Hyun Kim,^a LeTuyen Nguyen,^b Insup Noh^b and Cheal Kim*^a

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* Corresponding authors

^a Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Republic of Korea
E-mail: chealkim@seoultech.ac.kr
Fax: +82-2-973-9149
Tel: +82-2-970-6693

^b Department of Chemical and Biomolecular Engineering, and Convergence Program of Biomedical Engineering and Biomaterials, Seoul National University of Science & Technology, Seoul 139-743, Republic of Korea

Abstract

A new simple quinolone-based chemosensor 1 was synthesized for Zn²⁺. 1 exhibited selective fluorescence enhancement in the presence of Zn²⁺ with a 1 : 1 stoichiometry in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.019 μM) of 1 for Zn²⁺ is far lower than the World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn²⁺ in water samples and living cells. The sensing mechanism of Zn²⁺ by 1 via the chelation-enhanced fluorescence (CHEF) effect was supported by theoretical calculations. Therefore, 1 could be used in a practical system for monitoring Zn²⁺ in aqueous solution.

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Article information

DOI: https://doi.org/10.1039/C5RA05080D
Article type: Paper
Submitted: 23 Mar 2015
Accepted: 01 May 2015
First published: 04 May 2015

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RSC Adv., 2015,5, 41905-41913

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A highly selective CHEF-type chemosensor for monitoring Zn²⁺ in aqueous solution and living cells

J. J. Lee, S. A. Lee, H. Kim, L. Nguyen, I. Noh and C. Kim, RSC Adv., 2015, 5, 41905 DOI: 10.1039/C5RA05080D

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