Issue 50, 2015

Enhanced oral absorption of saquinavir mediated by PEGylated solid lipid nanoparticles

Abstract

PEGylated solid lipid nanoparticles containing saquinavir were prepared by a solvent diffusion method combined with ionic complexation, and exhibited a higher drug encapsulation efficiency, drug loading capacity and slowed drug release behavior. Moreover, the nanoparticles presented low cytotoxicity, higher transport ability across intestinal epithelial cells, and hence higher relative bioavailability which increased with enhancing of the polyethylene glycol content in the nanoparticles.

Graphical abstract: Enhanced oral absorption of saquinavir mediated by PEGylated solid lipid nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
25 Mar 2015
Accepted
09 Apr 2015
First published
09 Apr 2015

RSC Adv., 2015,5, 40341-40347

Author version available

Enhanced oral absorption of saquinavir mediated by PEGylated solid lipid nanoparticles

X. Hu, X. Kang, X. Ying, L. Wang and Y. Du, RSC Adv., 2015, 5, 40341 DOI: 10.1039/C5RA05283A

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