One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K2Cr2O7 as an efficient oxidant under base free conditions

Chao Wang; Huayou Hu; Juanfang Xu; Weiqiu Kan

doi:10.1039/C5RA06019B

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One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K₂Cr₂O₇ as an efficient oxidant under base free conditions†

Chao Wang,^a Huayou Hu,*^b Juanfang Xu^ab and Weiqiu Kan^b

Author affiliations

* Corresponding authors

^a School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, P. R. China

^b Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, P. R. China
E-mail: njuhhy@hotmail.com

Abstract

A one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed. A sub-equivalent amount of potassium dichromate was used as an oxidant under base free conditions. The transformation developed should be of economic efficiency.

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Article information

DOI: https://doi.org/10.1039/C5RA06019B
Article type: Communication
Submitted: 04 Apr 2015
Accepted: 30 Apr 2015
First published: 01 May 2015

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RSC Adv., 2015,5, 41255-41258

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One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K₂Cr₂O₇ as an efficient oxidant under base free conditions

C. Wang, H. Hu, J. Xu and W. Kan, RSC Adv., 2015, 5, 41255 DOI: 10.1039/C5RA06019B

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