A novel, rapid and green method of phosphorylation under ultrasound irradiation and catalyst free conditions

Abstract

The phosphorylation reaction of various N-acylamines, N-acylaminoesters N-acylaminoalcohols and N-acylsulfonamides with trimethylphosphite or triethylphosphite was effectively promoted under ultrasound irradiation, solvent and catalyst free conditions to produce the corresponding amidophosponate. This rapid method produced the products in short reaction times (5–15 min) and excellent yields (75–90%). This technique at a frequency of 40 kHz, strongly accelerates the process of formation of P–C bonds compared to the classic Arbuzov reaction.