An efficient and mild method for the synthesis of 4,5-disubstituted oxazoles has been developed. A series of 4,5-disubstituted oxazoles were prepared via [3 + 2] cycloaddition reaction of various isocyanides and acid chlorides in the presence of base. This method serves as an efficient preparation of 5-formyloxazole which might prove to be a synthetically useful intermediate.
D. K. Tiwari, J. Pogula and D. K. Tiwari, RSC Adv., 2015, 5, 53111 DOI: 10.1039/C5RA07668D
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
