PEG-assisted two-component approach for the facile synthesis of 5-aryl-1,2,4-triazolidine-3-thiones under catalyst-free conditions

Abstract

A straightforward and greener PEG-assisted protocol has been disclosed for the facile synthesis of 5-aryl-1,2,4-triazolidine-3-thiones via the two-component reaction of multifarious aromatic aldehydes and thiosemicarbazides using very convenient neutral reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity-oriented highly pure triazolidine scaffolds with broad substrate scope.