Issue 73, 2015

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

Abstract

In this paper, redox-sensitive mesoporous silica nanoparticles functionalized with polyethylene glycol (PEG) through a disulfide bond linker (MSNs–SS–PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs–SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG–SH). Meanwhile, the particle size, pore size and structural properties of these materials were characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and nitrogen adsorption–desorption measurements. Furthermore, the in vitro drug release behaviour of DOX-loaded MSNs–SS–PEG (DOX@MSNs–SS–PEG) was investigated. It was shown that DOX release was markedly accelerated with the increasing concentration of glutathione (GSH), while DOX was not released from the carrier materials in the absence of GSH. Cytotoxicity evaluation revealed the good biocompatibility of the blank nanoparticles and the DOX@MSNs–SS–PEG exhibited comparative anticancer activity to free DOX towards BEL-7402 cells. Therefore, the MSNs–SS–PEG might be a great potential carrier for anticancer drug delivery.

Graphical abstract: Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

Article information

Article type
Paper
Submitted
25 May 2015
Accepted
01 Jul 2015
First published
03 Jul 2015

RSC Adv., 2015,5, 59576-59582

Author version available

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

H. Gong, Z. Xie, M. Liu, H. Zhu and H. Sun, RSC Adv., 2015, 5, 59576 DOI: 10.1039/C5RA09774F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements