The novel quinolone derivatives synthesized by cyclization of α,β-ynones with primary amines were shown to be promising TNAP and IAP inhibitors. The mechanism of their formation was studied by the isolation of intermediates.
M. Miliutina, A. Ivanov, S. A. Ejaz, J. Iqbal, A. Villinger, V. O. Iaroshenko and P. Langer, RSC Adv., 2015, 5, 60054 DOI: 10.1039/C5RA10948E
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