nBu4NI-catalyzed intermolecular C–O cross-coupling reactions: synthesis of alkyloxyamines

Abstract

A practical and simple nBu₄NI-catalyzed C–O bond formation for the synthesis of alkyloxyamines was achieved under metal-free conditions. The reaction is applicable to the coupling of a range of benzylic and allylic hydrocarbons with N-hydroxyphthalimide and is tolerant of various functional groups. The reaction mechanism was primarily investigated and a radical process was proposed.