Issue 91, 2015
From the journal:

RSC Advances

A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused N-heteroarenes†

Satish P. Nikumbh,ab   Akula Raghunadh,a   V. Narayana Murthy,a   Rajesh Jinkala,a   Suju C. Joseph,ab   Y. L. N. Murthy,b   Bagineni Prasadc  and  Manojit Pal*c  

* Corresponding authors

a Technology Development Centre, Custom Pharmaceutical Services, Dr Reddy's Laboratories Ltd, Hyderabad 500049, India

b Department of Organic Chemistry, Andhra University, Visakhapatnam 530003, India

c Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

Abstract

A catalyst, ligand and solvent free method for double heteroarylation of N, O and S nucleophiles has been developed for the first time leading towards the synthesis of compounds containing an indole ring fused with pyrrolo-, furo- and thieno[2,3-b]quinoxaline moieties. This general and greener approach afforded novel compounds of medicinal importance.

Graphical abstract: A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused N-heteroarenes

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Article information

DOI
https://doi.org/10.1039/C5RA16727B
Article type
Communication
Submitted
31 Jul 2015
Accepted
24 Aug 2015
First published
24 Aug 2015

RSC Adv., 2015,5, 74570-74574

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A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused N-heteroarenes

S. P. Nikumbh, A. Raghunadh, V. N. Murthy, R. Jinkala, S. C. Joseph, Y. L. N. Murthy, B. Prasad and M. Pal, RSC Adv., 2015, 5, 74570 DOI: 10.1039/C5RA16727B

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