Unactivated carboxylic esters and primary amines undergo calcium-catalysed direct amide bond formation in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.
D. T. Nguyen, D. C. Lenstra and J. Mecinović, RSC Adv., 2015, 5, 77658 DOI: 10.1039/C5RA18288C
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