In vitro and in vivo applications of alginate/iron oxide nanocomposites for theranostic molecular imaging in a brain tumor model

Abstract

Nanocomposites composed of highly biocompatible and safe alginate and iron oxide nanoparticles have been employed to encapsulate doxorubicine for brain tumor therapy. The antitumor activity of nanocomposites was demonstrated using in vitro and in vivo tests. The results significantly indicated that the nanocomposites had great safety and potential for brain tumor therapy.