Issue 7, 2015

Organocatalytic asymmetric chlorinative dearomatization of naphthols

Abstract

An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.

Graphical abstract: Organocatalytic asymmetric chlorinative dearomatization of naphthols

Supplementary files

Article information

Article type
Edge Article
Submitted
09 Feb 2015
Accepted
25 Apr 2015
First published
27 Apr 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 4179-4183

Organocatalytic asymmetric chlorinative dearomatization of naphthols

Q. Yin, S. Wang, X. Liang, D. Gao, J. Zheng and S. You, Chem. Sci., 2015, 6, 4179 DOI: 10.1039/C5SC00494B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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