Issue 2, 2015
From the journal:

Journal of Materials Chemistry B

Design and delivery of camplatin to overcome cisplatin drug resistance†

Ruogu Qi,‡ab   Haihua Xiao,‡ab   Suhong Wu,ab   Yuxin Li,c   Yu Zhang*c  and  Xiabin Jing*a  

* Corresponding authors

a State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China
E-mail: xbjing@ciac.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

c National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, People's Republic of China
E-mail: zhangy259@nenu.edu.cn

Abstract

Camplatin, a prodrug formed via coining camphoric anhydride and cisplatin, was delivered in biodegradable nanoparticles. This camphoric acid and cisplatin co-delivery system exhibited enhanced anticancer activity compared to cisplatin and has successfully overcome cisplatin drug resistance.

Graphical abstract: Design and delivery of camplatin to overcome cisplatin drug resistance

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Article information

DOI
https://doi.org/10.1039/C4TB01146E
Article type
Communication
Submitted
12 Jul 2014
Accepted
02 Oct 2014
First published
02 Oct 2014

J. Mater. Chem. B, 2015,3, 176-179

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Design and delivery of camplatin to overcome cisplatin drug resistance

R. Qi, H. Xiao, S. Wu, Y. Li, Y. Zhang and X. Jing, J. Mater. Chem. B, 2015, 3, 176 DOI: 10.1039/C4TB01146E

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