We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.
S. Karthik, B. N. Prashanth Kumar, M. Gangopadhyay, M. Mandal and N. D. P. Singh, J. Mater. Chem. B, 2015, 3, 728 DOI: 10.1039/C4TB01583E
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