Issue 11, 2015
From the journal:

Journal of Materials Chemistry B

A proton-responsive ensemble using mesocellular foam supports capped with N,O-carboxymethyl chitosan for controlled release of bioactive proteins†

Qi Gan,abc   Jiaoyang Zhu,ab   Yuan Yuan,*ab   Honglai Liu,c   Yihua Zhub  and  Changsheng Liu*ab  

* Corresponding authors

a The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China
E-mail: yyuan@ecust.edu.cn, liucs@ecust.edu.cn

b Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China

c State Key Laboratory of Chemical Engineering and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, PR China

Abstract

A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-soluble N,O-carboxymethyl chitosan via the crosslinking of GPTMS. The delivery systems show excellent protein loading with programmable release in an acid environment. Moreover, the released proteins still preserve their conformational and biological activity.

Graphical abstract: A proton-responsive ensemble using mesocellular foam supports capped with N,O-carboxymethyl chitosan for controlled release of bioactive proteins

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5TB00219B
Article type
Communication
Submitted
30 Jan 2015
Accepted
16 Feb 2015
First published
18 Feb 2015

J. Mater. Chem. B, 2015,3, 2281-2285

Author version available

Download author version (PDF)

Permissions

Request permissions

A proton-responsive ensemble using mesocellular foam supports capped with N,O-carboxymethyl chitosan for controlled release of bioactive proteins

Q. Gan, J. Zhu, Y. Yuan, H. Liu, Y. Zhu and C. Liu, J. Mater. Chem. B, 2015, 3, 2281 DOI: 10.1039/C5TB00219B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements