Issue 43, 2015

Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels

Abstract

Bacterial nano-cellulose (BNC) hydrogel has been suggested as a promising biomaterial for artificial blood vessels. However, some properties of BNC do not achieve all of the requirements of a native blood vessel – compliance, for instance. In order to improve the properties of BNC tubes, poly(vinyl alcohol) (PVA) was introduced in the BNC tubes to make composites. Two types of pristine BNC tubes with different inner structures were produced in two bioreactors. A PVA tube and PVA–BNC tubular composites were made for comparison by using a thermally-induced phase separation method. The morphology, water permeability, cytotoxicity, and mechanical properties, including the axial stretch strength, suture retention, burst pressure, and compliance of all the tubes, were evaluated and compared. The results indicated that PVA impregnated into BNC tubes and then significantly improved the properties of BNC, especially the mechanical properties and water permeability. The BNC tube itself played a great role in the performances of the composites as the skeleton base material. The PVA–BNC composite tubes could constitute new biomaterial candidates for vascular grafts.

Graphical abstract: Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels

Article information

Article type
Paper
Submitted
13 Jun 2015
Accepted
17 Sep 2015
First published
17 Sep 2015

J. Mater. Chem. B, 2015,3, 8537-8547

Author version available

Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial blood vessels

J. Tang, L. Bao, X. Li, L. Chen and F. F. Hong, J. Mater. Chem. B, 2015, 3, 8537 DOI: 10.1039/C5TB01144B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements