Issue 45, 2015
From the journal:

Journal of Materials Chemistry B

Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings†

Yue Shi,‡abc   Vinh X. Truong,‡a   Ketav Kulkarni,b   Yue Qu,c   George P. Simon,a   Richard L. Boyd,d   Patrick Perlmutter,b   Trevor Lithgowc  and  John S. Forsythe*a  

* Corresponding authors

a Department of Material Science and Engineering, Monash Institute of Medical Engineering, Monash University, Victoria 3800, Australia
E-mail: john.forsythe@monash.edu

b Department of Chemistry, Monash University, Victoria 3800, Australia

c Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia

d Faculty of Medicine, Nursing and Health Sciences Anatomy and Developmental Biology, Monash University, Australia

Abstract

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.

Graphical abstract: Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

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Article information

DOI
https://doi.org/10.1039/C5TB01820J
Article type
Communication
Submitted
03 Sep 2015
Accepted
20 Oct 2015
First published
20 Oct 2015

J. Mater. Chem. B, 2015,3, 8771-8774

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Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Y. Shi, V. X. Truong, K. Kulkarni, Y. Qu, G. P. Simon, R. L. Boyd, P. Perlmutter, T. Lithgow and J. S. Forsythe, J. Mater. Chem. B, 2015, 3, 8771 DOI: 10.1039/C5TB01820J

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