Issue 4, 2016

Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

Abstract

Using 3,5-bis(trifluoromethyl)benzene-modified bisbenzimide H33258, bulged-out nucleobases on a DNA strand can be detected by the chemical shift change in 19F NMR. Based on this technique, single-nucleotide polymorphisms on a DNA sequence can be analyzed simultaneously.

Graphical abstract: Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2015
Accepted
08 Dec 2015
First published
08 Dec 2015

Analyst, 2016,141, 1214-1217

Author version available

Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

T. Sakamoto, D. Hasegawa and K. Fujimoto, Analyst, 2016, 141, 1214 DOI: 10.1039/C5AN02389K

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