Label-free fluorescence detection of microRNA based on target induced adenosine2–coralyne–adenosine2 formation

Jun-Jie Li; Qiang Xi; Wen-Fang Du; Ru-Qin Yu; Jian-Hui Jiang

doi:10.1039/C6AN00001K

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Label-free fluorescence detection of microRNA based on target induced adenosine₂–coralyne–adenosine₂ formation†

Jun-Jie Li,^a Qiang Xi,^a Wen-Fang Du,^a Ru-Qin Yu*^a and Jian-Hui Jiang*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: rqyu@hnu.edu.cn, jianhuijiang@hnu.edu.cn
Fax: +86-731-88822872
Tel: +86-731-88822577

Abstract

This study develops a simple and label-free biosensor for sensitive and selective detection of microRNA (miRNA) based on the formation of the adenosine₂–coralyne–adenosine₂ complex mediated by miRNA-specific polyadenosine extension.

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Article information

DOI: https://doi.org/10.1039/C6AN00001K
Article type: Communication
Submitted: 01 Jan 2016
Accepted: 03 Mar 2016
First published: 04 Mar 2016

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Analyst, 2016,141, 2384-2387

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Label-free fluorescence detection of microRNA based on target induced adenosine₂–coralyne–adenosine₂ formation

J. Li, Q. Xi, W. Du, R. Yu and J. Jiang, Analyst, 2016, 141, 2384 DOI: 10.1039/C6AN00001K

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