Issue 11, 2016
From the journal:

Analyst

SERS monitoring the dynamics of local pH in lysosome of living cells during photothermal therapy†

Rongxing Luo,‡a   Yinhui Li,‡a   Qifeng Zhou,a   Jing Zheng,*a   Dandan Ma,a   Pinting Tang,a   Sheng Yang,b   Zhihe Qingb  and  Ronghua Yang*ab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
E-mail: zhengjing2013@hnu.edu.cn, Yangrh@pku.ed.cn

b School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, China

Abstract

In this communication, we propose a gold nanorod-based SERS nanotracker to monitor the local pH change during photothermal therapy (PTT). The dynamic SERS analysis indicated that the local pH of the lysosome in living cells increased during the PTT which would be helpful to understand the cellular metabolic processes and further facilitate the photosensitizer screening and optimization.

Graphical abstract: SERS monitoring the dynamics of local pH in lysosome of living cells during photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C6AN00467A
Article type
Communication
Submitted
26 Feb 2016
Accepted
19 Apr 2016
First published
19 Apr 2016

Analyst, 2016,141, 3224-3227

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SERS monitoring the dynamics of local pH in lysosome of living cells during photothermal therapy

R. Luo, Y. Li, Q. Zhou, J. Zheng, D. Ma, P. Tang, S. Yang, Z. Qing and R. Yang, Analyst, 2016, 141, 3224 DOI: 10.1039/C6AN00467A

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